Recent advancements in solubilization and Gastroretentive techniques for Oral Drug Delivery of Proton Pump inhibitors: A comprehensive review
Keywords:proton pump inhibitors, solubilization, cyclodextrin inclusion complexes, Nanosuspension, solid dispersion, gastroretentive drug delivery systems, microballoons, Drug Delivery, gastric acidity
Proton pump inhibitors (PPIs) have been considered as safe and proficient therapeutic drugs enormously prescribed globally for management of acid-related disorders. PPIs have tendency to blockage proton pumps directly and therefore, considerably reduce gastric acid secretions. PPIs like lansoprazole, omeprazole, esomeprazole and dexlansoprazole are BCS class II medicines and meet challenge of inadequate drug dissolution in oral drug delivery and thus, require solubilization through various strategies like cyclodextrin inclusion complexes, nanosuspension, solid dispersion, microparticles, and solid dispersion pellets. PPIs also undergoes challenge of inadequate gastric residence time and therefore, development of gastroretentive drug delivery systems i.e. microbeads, microballoons, mucoadhesive and gastroretentive formulations, bilayer tablets, and super-porous hydrogel of PPIs has been crucial for acquiring vital local drug delivery in the gastrointestinal tract. This review provides comprehensive detail with regard to mechanism of action, pharmacokinetics/pharmacodynamics and physiochemical profile of PPIs. The primary objective of current review is recapitulation of research studies explored previously in order to overcome certain challenges in oral drug delivery of PPIs like low water solubility and inadequate gastric residence time.